Cousins was 21-for-30 from the field and also pulled down 12 rebounds in the loss.
The 56 points is a Kings single-game scoring record. It was also the most points by an NBA player this season.
It was the second game in a row that Cousins established a career-high scoring total. He dropped 48 on the Pacers Sunday in a 108-97 victory.
After last night's game, Charlotte's Kemba Walker praised Cousins.
"He's so gifted and talented. Cousins is one of the best big men I've ever played against," Charlotte guard Kemba Walker said. "He's pretty unstoppable."
Cousins was still disappointed with the loss.
"It was a tough loss. I was just sitting here (in the locker room) thinking how a lot of the plays early on could have changed the game," Cousins said. "But I think through all of the mistakes, we all left it on the floor. You hate to lose games like this."
Back-to-Back Games with 45 Points & 10 Rebounds - Last 30 Seasons DeMarcus Cousins Antawn Jamison Michael Jordan Charles Barkley— ESPN Stats & Info (@ESPNStatsInfo) January 26, 2016
Check out the highlights from last night's game:
Here are some highlights from Sunday's game: